Anti-angiogenic therapy for high-grade glioma
نویسندگان
چکیده
منابع مشابه
[Anti-angiogenic therapy for malignant glioma].
Glioblastoma(GBM)is the most malignant and frequent primary brain tumor. The current standard of care consists of maximum safe resection and radiotherapy with concomitant and subsequent temozolomide(TMZ)treatment. With this treatment plan, the prognosis of patients with GBM remains dismal, with a 5-year survival rate of<10%; thus development of effective, novel therapies is needed. Bevacizumab(...
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High-grade glioma is the most frequently occurring primary brain tumor and is associated with a poor prognosis. Current treatment regimens have had only a modest effect on the progressive course despite recent advances in surgery, radiotherapy, and chemotherapy. Gene therapy for brain tumors represents a novel and promising therapeutic approach and has been investigated clinically for the last ...
متن کاملAnti-Angiogenic Therapy for Malignant Glioma: Insights and Future Directions
Malignant gliomas comprise a significant number of new cases of brain cancer diagnosed in the United States each year. Despite recent therapeutic advances, they remain associated with high morbidity and mortality rates. The current standard of care for newly diagnosed malignant gliomas includes surgical resection followed by radiotherapy with concomitant and adjuvant Temozolomide. Bevacizumab, ...
متن کاملRapidArc: Initial experience in high grade glioma
Background: Identify the optimal technique of radiotherapy for patients with high grade glioma. Our initial year of experience with RapidArc radiation therapy. Materials and Methods: Planning CT scans of 50 patients with grade IV glioma were reviewed and three plan sets by 3D Conformal Radiotherapy (3DCRT), Intensity Modulated Radiotherapy (IMRT) and Rapid Arc (RA) were generated and the plans ...
متن کاملTemozolomide for high grade glioma.
BACKGROUND High grade glioma (HGG) is an aggressive form of brain cancer. Treatment of HGG usually entails biopsy, or resection if safe, followed by radiotherapy. Temozolomide is a novel oral chemotherapy drug that penetrates into the brain and purportedly has a low incidence of adverse events. OBJECTIVES To assess whether temozolomide has any advantage for treating HGG in either primary or r...
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ژورنال
عنوان ژورنال: Cochrane Database of Systematic Reviews
سال: 2018
ISSN: 1465-1858
DOI: 10.1002/14651858.cd008218.pub4